HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(Piperidin-4-yl)sulfanyl]pyridine--hydrogen chloride (1/2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 13825040 | HCID 13825040 | — |
| Product | 4-[(Piperidin-4-yl)sulfanyl]pyridine--hydrogen chloride (1/2) | HCID 21906071 | — |
Reaction Steps
A solution of phenyl 4-[(4-pyridyl)thio]-1-piperidine-carboxylate (5.0 g) in conc. hydrochloric acid (50 ml) was refluxed for 7 hours and concentrated to dryness in vacuo. The crystalline residue was washed with isopropanol and recrystallized from methanol to give 4-[(4-pyridyl)thio]piperidine dihydrochloride (2.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04735952 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-6057c1253b1a4551b178773547774813 |
| Source note | uspto-grants-1988_04 |