Aminoisobutyric acid → HCID 13770334, compound

HRID 648612Notes

Reaction equation

HRID 648612 reaction equation
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].[C:8](Cl)(=[O:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[OH-].[Na+]>CCOCC.O>[C:8]([NH:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4])(=[O:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

6

Reactant 3

HCID 6119Aminoisobutyric acidHCID 14798Sodium HydroxideHCID 67340Hexanoyl chloride

Product 1

HCID 13770334HCID 13770334, compoundYield 49%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

2-Aminoisobutyric acid (2.0 g, 19.4 mmol) and n-hexanoyl chloride (3.0 g, 22.4 mmol) were reacted in the presence of NaOH (1.6 g, 40 mmol) in a mixture of ether and water using the method described in Example 5, Part A. The title compound (1.90 g, 49%) was obtained after crystallization from benzene, m.p. 141°-143° C.

Sources & evidence

ORD record
ord-0b665318c3014a65a76cc1e9fe9590a7
Source dataset
uspto-grants-1988_04
Patent number
US04735962

Reaction notes

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