反应详情

4-Phenylbutanoic acid prepared as described in Example 56, Part A was dissolved in glacial acetic acid (25 ml). Platinum oxide (0.1 g) was added and the solution was hydrogenated in the Paar shaker at up to 55 p.s.i. until hydrogen uptake ceased (6.5 hours). The catalyst was removed by filtration and the acetic acid was removed in vacuo. The product crystallized and was recrystallized from Et2O (20 ml) to give title compound (1.18 g, 77%), m.p. 85°-88° C.

1. custom(6.5 hours)
2. customThe catalyst was removed by filtration
3. customthe acetic acid was removed in vacuo
4. customThe product crystallized
5. customwas recrystallized from Et2O (20 ml)