Sodium Hydroxide → HCID 131715485, compound

HRID 648626Notes

Reaction equation

HRID 648626 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:15]([C:25]([NH2:27])=[O:26])[C:16]2[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=2)[CH3:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:29]>C(O)C>[Na+:29].[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:15]([C:25]([NH2:27])=[O:26])[C:16]2[CH:17]=[CH:18][C:19]([C:20]([O-:22])=[O:21])=[CH:23][CH:24]=2)[CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20145110HCID 20145110, compound

Product 1

HCID 131715485HCID 131715485, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
20 °C

Procedure

An amount of 8.4 gm (0.0229 mol) of 4-[(1-(2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid was dissolved at 60° to 65° C. in 80 ml of ethanol. To this solution 22.9 ml of 1N sodium hydroxide solution were added under stirring, and stirring was continued for 30 minutes. After cooling to 20° C., a precipitate was thereby obtained. After further cooling to 0° C., the precipitate was filtered and washed with cold ethanol and ether. The precipitate thus obtained (m.p.: 250°-251° C.) was recrystallized from ethanol/water (7:3).

Workup

  1. stirringstirring
  2. customa precipitate was thereby obtained
  3. temperatureAfter further cooling to 0° C.
  4. filtrationthe precipitate was filtered
  5. washwashed with cold ethanol and ether
  6. customThe precipitate thus obtained (m.p.: 250°-251° C.)
  7. customwas recrystallized from ethanol/water (7:3)

Sources & evidence

ORD record
ord-1bdd543d871d4e9381bd8abec9800910
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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