HCID 57082612, compound → HCID 20145110, compound

HRID 648628Notes

Reaction equation

HRID 648628 reaction equation
C([O:8][C:9](=[O:34])[C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH3:21])[C:17]([NH2:19])=[O:18])=[CH:12][CH:11]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[N:28]1([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[CH:20]([CH:16]([C:17]([NH2:19])=[O:18])[C:13]2[CH:12]=[CH:11][C:10]([C:9]([OH:34])=[O:8])=[CH:15][CH:14]=2)[CH3:21])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1

Participants

5

Reactant 2

HCID 57082612HCID 57082612, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20145110HCID 20145110, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A quantity of 0.46 gm (1 mmol) of 4-[(1-(2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid benzyl ester in 20 ml of ethanol was hydrogenated at 0.25 gm of palladium/charcoal at 50° C. and a hydrogen pressure of 5 bar. After five hours the catalyst was filtered off over celite, and the filtrate was evaporated in vacuo. The evaporation residue was recrystallized from ethanol/water (8:2).

Workup

  1. filtrationAfter five hours the catalyst was filtered off over celite
  2. customthe filtrate was evaporated in vacuo
  3. customThe evaporation residue was recrystallized from ethanol/water (8:2)

Sources & evidence

ORD record
ord-cb5775894b01473fbaad9b2b1669c273
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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