Acetic Anhydride → HCID 20145181, compound

HRID 648640Notes

Reaction equation

HRID 648640 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:6]([CH:8]([CH:10]([C:20]([NH2:22])=[O:21])[C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)[CH3:9])[CH:7]=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[C:29]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:6]([CH:8]([CH:10]([C:20]([NH2:22])=[O:21])[C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)[CH3:9])[CH:7]=1)(=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20145241HCID 20145241, compound

Product 1

HCID 20145181HCID 20145181, compound

Procedure

An amount of 0.10 gm (0.262 m mol) of 4-[(1-(5-amino-2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid in 1 ml of acetic anhydride was stirred for six hours at 20° C., evaporated in vacuo, and distilled off several times with toluene, and the evaporation residue was recrystallized from ether.

Workup

  1. customevaporated in vacuo
  2. distillationdistilled off several times with toluene
  3. customthe evaporation residue was recrystallized from ether

Sources & evidence

ORD record
ord-8bf896ff200b4485b23d43d618bb3e6c
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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