Hydrochloric Acid → HCID 20145189, compound

Participants

Reaction Steps

An amount of 0.224 gm (5.92 m mol) of sodium borohydride was added in portions with stirring to a solution of 1 gm (2.63 m mol) of 4-[(1-(2-(4-oxo-piperidino)-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid in 20 ml of absolute ethanol. After stirring for 1.5 hours at room temperature, the reaction mixture was adjusted acidic by means of 2N hydrochloric acid, evaporated in vacuo, mixed with water and ethyl acetate, and adjusted to a pH of 6 by means of 2N sodium hydroxide solution. After extraction several times with ethyl acetate, the organic phase was dried and filtered, and the extract was evaporated in vacuo. The evaporated in vacuo. The evaporation residue was recrystallized from petroleum ether.

Provenance & Evidence