Methanol → HCID 57287281, compound

Participants

Reaction Steps

A mixture of 2 gm (5.46 m mol) of 4-[(1-(2-piperidinophenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid, 0.53 gm of methanol, 0.38 ml of conc. sulfuric acid, and 1.65 ml of 1,2-dichloro-ethane was refluxed for 24 hours, then evaporated in vacuo, dissolved in chloroform, and extracted with dilute sodium bicarbonate solution. The organic phase was washed with water, dried, filtered, and evaporated in vacuo. The evaporation residue was purified by column chromatography on silica gel (toluene/acetone=5:1).

Provenance & Evidence