HCID 53765668, compound → HCID 20145256, compound

HRID 648654Notes

Reaction equation

HRID 648654 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:21][C:22]([CH2:24][C:25]2[CH:35]=[CH:34][C:28]([CH:29]=[CH:30][C:31]([OH:33])=[O:32])=[CH:27][CH:26]=2)=[O:23])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:21][C:22]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:34][CH:35]=2)=[O:23])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 53765668HCID 53765668, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20145256HCID 20145256, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

An amount of 0.91 gm (2 m mol) of 4-[N-(α-(4-methyl-phenyl)-2-piperidino-benzyl)-aminocarbonylmethyl]-cinnamic acid was dissolved in 50 ml of methanol, and, after the addition of 0.5 gm of palladium (10% on charcoal), the mixture was catalytically hydrogenated at ambient temperature under a hydrogen pressure of 3 bar. After the hydrogen uptake ended, the catalyst was filtered off and recrystallized from a small amount of acetonitrile.

Workup

  1. customwas catalytically hydrogenated at ambient temperature under a hydrogen
  2. filtrationthe catalyst was filtered off
  3. customrecrystallized from a small amount of acetonitrile

Sources & evidence

ORD record
ord-a400d4def7944ae78b7ecf6ba11a062e
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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