HCID 57102019, compound → HCID 20145225, compound

HRID 648663Notes

Reaction equation

HRID 648663 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:17]([C:31]([NH2:33])=[O:32])[C:18]2[CH:30]=[CH:29][C:21]([CH:22]=[CH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:20][CH:19]=2)[CH2:14][CH2:15][CH3:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)C.[Pd]>[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]([CH:17]([C:31]([NH2:33])=[O:32])[C:18]2[CH:19]=[CH:20][C:21]([CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:29][CH:30]=2)[CH2:14][CH2:15][CH3:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 57102019HCID 57102019, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20145225HCID 20145225, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

An amount of 0.60 gm (1.34 m mol) of ethyl 4-[(1-(2-piperidino-phenyl)-1-butyl)-aminocarbonylmethyl]-cinnamate was hydrogenated in 10 ml of ethanol on 0.20 gm of 10% palladium/charcoal at ambient temperature under 5 bar of hydrogen. The mixture was filtered and concentrated by evaporation in vacuo.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-3087471c89744d09b88571c819c86720
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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