Ammonia → HCID 20145272, compound

Participants

Reaction Conditions

Reaction Steps

Two hundred thirty-four milligrams (1.22 m mol) of 4-toluene-sulfochloride were added in two batches to 520 mg (1.22 m mol) of ethyl 4-[(α-aminocarbonyl-2-piperidino-benzyl)-aminocarbonylmethyl]-benzoate in 0.22 ml of pyridine, and the mixture was heated to 50° C. After two hours and then one hour later, the same quantities of pyridine and 4-toluene-sulfochloride were again added, and the resulting mixture was heated for a further hour at 50° C. After the mixture was left to stand for two days at 20° C., 2N ammonia was added, and the mixture was extracted with chloroform. The chloroform solution was extracted twice with water. After drying and filtering, the solution was concentrated by evaporation in vacuo. The evaporation residue was purified by column chromatography on silica gel [chloroform/methanol (10:1)].

Provenance & Evidence