Water → HCID 13808698, compound

Participants

Reaction Steps

To a solution of 0.2 g of methyl 3-oxo-2-[3-(4-phenyl-1-piperazinyl)propyl]-2,3,4,5-tetrahydro-1-benzothiepin-2-carboxylate obtained in Example 2 in 20 ml of methanol, 50 mg of sodium borohydride is added in small portions with stirring. After stirring for one hour, the reaction mixture is treated with water and extracted with ethyl acetate. The organic layer is washed with water, dried, and evaporated under reduced pressure. The residue is recrystallized from ethyl acetate-hexane, to give 0.15 g of methyl 3-hydroxy-2-[3-(4-phenyl-1-piperazinyl)propyl]-2,3,4,5-tetrahydro-1-benzothiepin-2-carboxylate as crystals, obtained in Example 7: m.p. 152°-154° C.

Provenance & Evidence