反应详情

A mixture of 9.3 g of 2-amino-3-fluoro-benzoic acid and 18,6 ml of α-chloropropionyl chloride was refluxed for 3 hours and excess acid chloride was distilled off. The residue was concentrated under reduced pressure at 70° C. for 2 hours to obtain 2-(1-chloroethyl)-8-fluoro-4H-3,1-benzoxazine-4-one which was used as is for the next step.

1. temperaturewas refluxed for 3 hours
2. distillationexcess acid chloride was distilled off
3. concentrationThe residue was concentrated under reduced pressure at 70° C. for 2 hours