Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Acetamidothiazole | HCID 17625 | — |
| 반응물 | 2-(1-Chloroethyl)-8-fluoro-4H-3,1-benzoxazin-4-one | HCID 20145691 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | HCID 178418244 | HCID 178418244 | — |
| 생성물 | 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide | HCID 13423086 | 39.2% |
반응 단계
Using the procedure of Step A of Example 6, a solution of 17 g of N-(2-thiazolyl)-acetamide in 340 ml of tetrahydrofuran, 160 ml of butyllithium-hexane solution and 0.06 moles of the product of Step D in 130 ml of tetrahydrofuran were reacted to obtain 8.7 g of 2-[(2-chloro-1-oxo-propyl)amino]-β-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide melting towards 170° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04736033 |
| 출처 데이터셋 | uspto-grants-1988_04 |
| ORD ID | ord-40cc4c345e2940eeba6060588d9cfda2 |
| 출처 메모 | uspto-grants-1988_04 |