HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-pentyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Acetamidothiazole | HCID 17625 | — |
| Edukt | 4H-3,1-Benzoxazin-4-one, 2-(1-chlorobutyl)-8-(trifluoromethyl)- | HCID 13423080 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | HCID 178418244 | HCID 178418244 | — |
| Produkt | 2-[(2-chloro-1-oxo-pentyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide | HCID 13423083 | 72,6% |
Reaktionsschritte
Using the procedure of Step A of Example 6, a solution of 6.94 g of N-(2-thiazolyl)-acetamide in 280 ml of tetrahydrofuran and 70 ml of a butyllithium-hexane solution and a solution of 7.8 g of the product of Step A in 40 ml of tetrahydrofuran were reacted to obtain 8.3 g of 2-[(2-chloro-1-oxo-pentyl)-amino]-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzene propanamide melting towards 184°-186° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04736033 |
| Quelldatensatz | uspto-grants-1988_04 |
| ORD ID | ord-3d8b06f518f645bca6badbec8e481246 |
| Quellennotiz | uspto-grants-1988_04 |