Ammonia → HCID 13822372, compound

HRID 648758Notes

Reaction equation

HRID 648758 reaction equation
Cl.[CH3:2][N:3]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=1[Cl:23])[C:4]([C:6]1[S:10][C:9]2=[N:11][CH2:12][CH2:13][N:8]2[C:7]=1[CH3:14])=[O:5].N>O>[Cl:23][C:17]1[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:16]=1[CH2:15][N:3]([CH3:2])[C:4]([C:6]1[S:10][C:9]2=[N:11][CH2:12][CH2:13][N:8]2[C:7]=1[CH3:14])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19862157HCID 19862157, compound

Product 1

HCID 13822372HCID 13822372, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Dissolved in water was 3.6 g (0.01 mole) of the thus-obtained 2-[N-methyl-N-(2,4-dichlorobenzyl)carbamoyl]-3-methyl-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride. While stirring the solution at room temperature, aqueous ammonia was added dropwise. The resultant precipitate was collected by filtration and then washed and purified with a great deal of water, thereby obtaining 3.0 g of N-(2,4-dichlorobenzyl)-N,3-dimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide (melting point: 55°-60° C.; light yellowish crystals).

Workup

  1. filtrationThe resultant precipitate was collected by filtration
  2. washwashed
  3. custompurified with a great deal of water

Sources & evidence

ORD record
ord-3a46aae247d14a5dafa2b65294788afe
Source dataset
uspto-grants-1988_04
Patent number
US04736038

Reaction notes

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