反应详情

温度

80 °C

20 g (0.052 moles) of monooctadecenyl phosphate having a purity of 90% (AV1=165.0, AV2=323.2) was charged into a reactor, to which 58.8 ml of 1N potassium hydroxide aqueous solution was added and agitated at 80° C. to obtain uniform solution, at which the acid value of the reaction system was 40.2. While keeping the reaction system at 80° C., 24.1 g (0.26 moles) of epichlorohydrin was gradually dropped, followed by agitation at the temperature for 6 hours. The acid value of the reaction system was approximately zero, revealing that the reaction rate of the phosphoric monoester was almost 100%. The resulting product was collected by HPLC and the solvent was distilled off under reduced pressure to obtain 16.9 g (yield 67.8%) of potassium octadecenyl 2-hydroxy-3-chloropropyl phosphate.

1. additionwas added
2. customto obtain uniform solution
3. customat 80° C.
4. customThe resulting product was collected by HPLC
5. distillationthe solvent was distilled off under reduced pressure