1,2-Dibromoethane → HCID 14150219, compound

Participants

Reaction Steps

In a manner similar to the procedure described in Example B except that a 100 milliliter three-necked Morton flask was used, 10.0 grams (43.0 mmol) of ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate, 14.8 grams (108.0 mmol) of anhydrous potassium carbonate, 40 milliliters of anhydrous dimethylformamide and 3.7 milliliters (43.0 mmol) of 1,2-dibromoethane were reacted for a period of 8 days to give 5.19 grams (20.0 mmol) of ethyl 1-(4-cyanophenylaminocarbonyl)cyclopropanecarboxylate as a colorless solid having a melting point of 132.0° C.-133.5° C. The total yield was 47 percent. An analytical sample was prepared by recrystallization from hexane-ethyl acetate having a melting point of 133.0° C.-134.0° C. NMR analysis of the product indicated the following:

Provenance & Evidence