Thiourea → HCID 131715209, compound

Participants

Reaction Steps

A solution of the crude reaction mixture from Example 11 and 4.5 g thiourea in 150 ml methanol was heated at reflux temperature for 1.5 hours. Removal of the methanol in vacuo left a viscous oil which afforded a white solid upon trituration with ethyl acetate and filtration. The yield of the title isothiouronium bromide salt, m.p. 157°-164°(dec.), was 22.2 g.

Provenance & Evidence