Toluene → 4-Formylbenzoyl chloride

Participants

Reaction Steps

Thionyl chloride (300 ml) was added to a mixed solution of commercially available terephthalaldehydic acid (350 g), toluene (700 ml) and pyridine (2 ml), followed by stirring at room temperature, thereafter heating the mixture on a water bath at 60° C. with stirring, further heating to 110° C. on a mantle heater, cautiously adding thionyl chloride (100 ml), heating at 150° C. for 3 hours with stirring, distilling off excess thionyl chloride under reduced pressure and distilling the residue under reduced pressure to obtain terephthalaldehydic acid chloride (328 g) (b.p. 133°~134° C./14 mmHg).

Provenance & Evidence