3-Fluoro-4-methoxybiphenyl → 3'-Fluoro-4'-methoxy-4-acetylbiphenyl

HRID 648876Notes

Reaction equation

HRID 648876 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:16](Cl)(=[O:18])[CH3:17].[Al+3].[Cl-].[Cl-].[Cl-]>C(=S)=S>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13]([C:16](=[O:18])[CH3:17])=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 141221243-Fluoro-4-methoxybiphenylHCID 86587523acetyl chloride AlCl3

Product 1

HCID 143886483'-Fluoro-4'-methoxy-4-acetylbiphenylYield 82%

Reagents, catalysts & solvents 1

HCID 6348Carbon DisulfideSolvent

Procedure

3-Fluoro-4-methoxybiphenyl was acetylated with acetyl chloride/AlCl3 in carbon disulfide in the usual way. The product was twice recrystallized from toluene to obtain 3'-fluoro-4'-methoxy-4-acetylbiphenyl (yield: 82%), m.p. 149°~149.5° C.

Workup

  1. customThe product was twice recrystallized from toluene

Sources & evidence

ORD record
ord-52bdb8f0dea84415b90d632c1345cd3e
Source dataset
uspto-grants-1988_04
Patent number
US04737313

Reaction notes

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