Chloroacetyl chloride → HCID 14150226, compound

HRID 648882Notes

Reaction equation

HRID 648882 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH:6]1[CH:11]=[C:10]([CH:12]([OH:21])[C:13]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[N:9]=[CH:8][CH:7]=1>C(#N)C>[Cl:1][CH2:2][C:3]([O:14][CH:13]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][N:20]=1)[C:12]([C:10]1[CH:11]=[CH:6][CH:7]=[CH:8][N:9]=1)=[O:21])=[O:4]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 95624α-Pyridoin

Product 1

HCID 14150226HCID 14150226, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

Chloroacetyl chloride (1.4 g, 0.0123 mole) in an equal amount of dry acetonitrile was added dropwise with stirring to 5.4 g (0.0252 mole) of α-pyridoin in 50 ml of dry acetonitrile. The reaction mixture was stirred one hour. The orange solid was filtered off and washed with acetonitrile.

Workup

  1. filtrationThe orange solid was filtered off
  2. washwashed with acetonitrile

Sources & evidence

ORD record
ord-8bedfbcd13034c55b9ce1ce250c80730
Source dataset
uspto-grants-1988_04
Patent number
US04737439

Reaction notes

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