Pyridine → HCID 20144038, compound

Participants

Reaction Steps

To 2.14 g (0.01 mole) of α-pyridoin in 50 ml of acetonitrile was added 0.80 g (0.01 mole) of pyridine and then 1.65 g (0.01 mole) of p-cyanobenzoyl chloride portionwise with stirring. Stirring was continued for 1/2 hour. Then 150 ml of dichloromethane was added, the organic phase washed thoroughly with water, dried and evaporated to an oily solid residue. The residue was stirred with 80% hexane and 20% acetone to obtain a solid, 1.7 g (50%). After recrystallization from hexane-acetone, 0.9 g (53%), m.p., 152°-154° C., of NA-VI was recovered.

Provenance & Evidence