Formic Acid → Hydrazinecarboxaldehyde, 2-(4-nitrophenyl)-

Participants

Reaction Steps

Then, according to the method described in Japanese Patent Application (OPI) No. 74729/79, 1-formyl-2-(4-aminophenyl)hydrazine was produced. That is, to 1.6 liters of acetonitrile was added 45 g of 4-nitrophenylhydrazine and then 322 g of formic acid was gradually added to the mixture with stirring, whereby a homogeneous solution was obtained. After 20 minutes, crystals began to deposit. After further performing the reaction for 2 hours at an inside temperature of 80° C., the reaction mixture was cooled and crystals thus formed were collected by filtration, washed with acetonitrile and dried to provide 495 g of 1-formyl-2-(4-nitrophenyl)hydrazine having a melting point of 184°-186° C.

Provenance & Evidence