L-Proline → HCID 14127455, compound

Participants

Reaction Steps

To 80 ml of tetrahydrofuran, 1.0 g of proline was suspended, and 2.0 g of 2-methylthio-1,3-dithiolium perchlorate was gradually added thereto under stirring at room temperature. The mixture was stirred at room temperature for 1 hour, and the solvent was distilled off under reduced pressure. The residue was dissolved in a mixture comprising 50 ml of water and 50 ml of ethyl acetate. The aqueous layer was separated and the solvent was distilled off under reduced pressure, whereby 1.6 g (yield: 63%) of 1-(1,3-dithiol-2-ylidene)-2-carboxypyrrolidinium perchlorate (Compound No. 43) was obtained as yellow oily residue.

Provenance & Evidence