Potassium Hydroxide → HCID 14155429, compound

Participants

Reaction Steps

To a solution of 4.4 g of 1,3,4,16b-tetrahydro-2-ethoxycarbonyl-2H,10H-indolo[2,1-c]pyrazino[1,2-a][1,4]benzodiazepine in 88 ml ethanol is added 24 ml of 50% potassium hydroxide solution. The reaction mixture is heated at reflux temperature for 6 hours. The solvent is evaporated to dryness under reduced pressure and the residue extracted with a mixture of 350 ml of diethyl ether and 250 ml of water. The ethereal extract is washed with water, separated and then dried over anhydrous magnesium sulfate. The solvent is evaporated to yield 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino[1,2-a][1,4]benzodiazepine which is converted to the hydrochloride salt, mp 263° dec.

Provenance & Evidence