Formaldehyde → HCID 13474239, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-methylpiperazine (2.21 ml, 20 m mole), DMF (25 ml), chloroform (6 ml) and 1,2-bis(3,5-dioxopiperazin-1-yl)-ethane (2.54 g, 10 m mole) was stirred at 70° C. for ten minutes. The mixture was treated with 37% aqueous formaldehyde solution (1.62 ml) and was stirred at the same temperature for further 2 hours. Then, the same procedure as in Example 3 was made to give the titled compound (3.3 g; yield 68%).

Provenance & Evidence