Formaldehyde → HCID 13474247, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-phenylpiperazine (2.9 g, 17.7 m mole), DMF (20 ml), absolute ethanol (5 ml) and dl-1,2-bis(3,5-dioxopiperazin-1-yl)-propane (2,0 g, 7.4 m mole) was stirred at 150° C. for ten minutes. The mixture was treated with 37% aqueous formaldehyde solution (1.40 ml) and was stirred at the same temperature for further 1.5 hours. Then, the same procedure as in Example 3 was made to give the titled compound (2.9 g; yield 88%).

Provenance & Evidence