4,4'-(Propane-1,2-diyl)bis{1-[(morpholin-4-yl)methyl]piperazine-2,6-dione} → HCID 14100461, compound

Participants

Reaction Steps

Water (200 ml) was added to dl-1,2-bis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl)-propane (4.0 g) obtained in Example 1 and the mixture was stirred at room temperature for 0.5 hours. Then, the mixture was filtered and the filtrate was stirred at room temperature for further 3 hours. The reaction mixture was freezed on a dry ice-acetone bath and the freezed mixture was allowed to stand at room temperature to give an aqueous suspension. Colorless solids, which precipitated in the aqueous suspension, were collected by filtration and dried over phosphorus pentaoxide under a reduced pressure to give the titled compound (1.22 g; yield 40%).

Provenance & Evidence