Potassium Carbonate → HCID 13747808, compound

Participants

Reaction Steps

4.8 g 4-(4-(1,1-Dimethylethyl)-2-thiazolyl)-1-phenylmethyl-piperidine, 2 g K2CO3 and 50 ml 1,2-dichloroethane are treated dropwise at -5° under stirring with 3.2 g chloroformic acid vinyl ester. The mixture is stirred 2 hours at room temperature and evaporated. The residue is partitioned between ethyl ether and water. The ether phase is evaporated and the residue dissolved in 30 ml methanol and 30 ml 20% aqueous hydrochloric acid. The mixture is heated 1 hour at 60° and evaporated. The residue is partitioned between aqueous NaOH and ether. The ether phase is treated with maleic acid to yield the hydrogenmaleinate of the title compound, m.p. 141°-142° (ethanol/ether).

Provenance & Evidence