1-Bromo-2-methylpropane → HCID 13649199, compound

Participants

Reaction Steps

5-(1-Piperazinylcarbonyl)oxindol hydrochloride (1.0 g), 1.2 g of DBU, and 0.73 g of isobutyl bromide were suspended in 15 ml of acetonitrile and the suspension was reflexed for 6 hours. To the mixture were then added 0.6 ml of triethylamine and 0.73 g of isobutyl bromide and the mixture was further reflexed for 8 hours. The reaction mixture was poured into a saturated aqueous solution of sodium hydrogencarbonate and extracted with chloroform. The chloroform layer was washed with a saturated saline solution and dried over sodium sulfate. The residue obtained after the solvent was distilled off was purified by silica-gel column chromatography (eluent: dichloromethane:methanol=20:1). The product was converted into the hydrochloride with acetone and hydrochloricacid, and recrystallized from a mixture of ethanol and methanol to give 0.39 g of 5-(4-isobutyl-1-piperazinylcarbonyl)oxindol hydrochloride.

Provenance & Evidence