Water → HCID 13649215, compound

Participants

Reaction Steps

To a suspension comprising 1.0 g of dihydrochloric acid salt of 5-[2-(1-piperazinyl)acetyl]oxindol, 0.63 gof potassium carbonate, 5 ml of water and 10 ml of acetone was added dropwise a solution of 0.63 g of m-chlorobenzoyl chloride in 2 ml of acetone under ice-cooling with stirring, and the mixture was stirred for 1.5 hours at the same temperature. After completion of reaction, the reaction mixture was poured into ice-water and extracted with chloroform. The chloroform layer was washed, in turn, with water and a saturated saline solution, and dried over sodium sulfate. The solvent was then distilled off under reduced pressure. The resultant residue was purified by silica-gel column chromatography (eluent: chloroform:methanol=20:1) and recrystallized from a mixture of ethanol and chloroform to give 0.34 g of 5-[2-[4-(3-chlorobenzoyl)-1-piperazinyl]acetyl]oxindol.

Provenance & Evidence