Ethyl benzoate → HCID 13649194, compound

Participants

Reaction Steps

To 100 ml of ethanol were added 1.36 g of ethyl benzoate, 0.5 g of sodium ethylate and 2.6 g of 5-(piperazinylcarbonyl)oxindol hydrochloride and the mixture was reacted in an autocrave at 140° to 150° C. under 110 atm for 6 hours. After cooling, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in 200 ml of chloroform. After washing, in turn, with 1% aqueous potassium carbonate solution, dilute hydrochloric acid, and water, the chloroform solution was dried over anhydrous sodium sulfate and the solvent was distilled off. The resultant residue was purified by silica-gel column chromatography [silica-gel: WAKO C-200, eluent: chloroform:methanol (V/V)=20:1], and the crude crystal was recrystallized from methanol to give 215 mg of 5-(4-benzoyl-1-piperazinylcarbonyl)oxindol.

Provenance & Evidence