P-Anisidine → HCID 4399373, compound

HRID 648992Notes

Reaction equation

HRID 648992 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.Br[CH2:11][C:12]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)=[CH:13][C:14](OCC)=[O:15]>C(O)C>[F:25][C:22]1[CH:21]=[CH:20][C:19]([C:12]2[CH2:11][N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:14](=[O:15])[CH:13]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 54208606HCID 54208606, compound

Product 1

HCID 4399373HCID 4399373, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

p-Anisidine (1793 g, 14.6 mol) and ethyl 4-bromo-3-(4-fluorophenyl)-2-butenoate (1393 g, 4.9 mol) are combined in ethanol (6 L), and the mixture is stirred for 24 hr. The precipitate which forms is collected by filtration, washed with ethanol, and dried under vacuum for 24 hr at 60° C. to give the title compound.

Workup

  1. filtrationThe precipitate which forms is collected by filtration
  2. washwashed with ethanol
  3. customdried under vacuum for 24 hr at 60° C.

Sources & evidence

ORD record
ord-ed64e49df1ac42d7b6f7ac4b13938458
Source dataset
uspto-grants-1988_04
Patent number
US04737511

Reaction notes

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