Nitric Acid → HCID 10444779, compound

Participants

Reaction Conditions

Reaction Steps

Nitric acid (70%, 14 mL, 0.22 mol) is added dropwise to a solution of 3-ethyl-4-(4-fluorophenyl)-1,5-dihydro -2H-pyrrol-2-one (37.6 g, 0.18 mol) in concentrated sulfuric acid (140 mL) while the temperature is maintained at 0°-5° C. The mixture is stirred for 2 hr at 0° C., and then is poured onto 2500 g of ice. The resulting precipitate is collected by filtration, and washed with water until the washes are neutral. Recrystallization of the solid from ethanol followed by drying under vacuum at 50° C. for 24 hr provides the title compound.

Provenance & Evidence