反应详情

To a solution of 7 g of 7-methylbenzo[b]thiophene in abs. tetryhydrofuran are added dropwise at -78°, 30 ml of a 1.6M solution of n-butyllithium in hexane. After 20 minutes 5.5 g of perchloryl fluoride are introduced whereby the reaction temperature is maintained below -60°. After 30 minutes at -78° the temperature is slowly raised to 0°. The mixture is then mixed with water and the organic phase separated, washed, dried and concentrated under vacuum. The residue is chromatographed (eluant: n-hexane) to obtain the title compound as an oil.

1. additiontetryhydrofuran are added dropwise at -78°
2. temperatureis maintained below -60°
3. temperatureAfter 30 minutes at -78° the temperature is slowly raised to 0°
4. customthe organic phase separated
5. washwashed
6. customdried
7. concentrationconcentrated under vacuum
8. customThe residue is chromatographed (eluant: n-hexane)