反应详情

420 mg of borontrifluoride-etherate are added to a mixture of 2 g of 7-methylbenzo[b]thiophene and 1.4 ml acetanhydride at 50° and the mixture warmed to 60° for 80 minutes. The resulting mixture is poured onto ice, extracted with ether and the organic phase washed, dried and concentrated on a rotary evaporator. The residue is chromatographed on silica gel (eluant: n-hexane) to obtain the title compound, contaminated with the 2-acetylisomer, as an oil for direct further reaction.

1. temperaturethe mixture warmed to 60° for 80 minutes
2. additionThe resulting mixture is poured onto ice
3. extractionextracted with ether
4. washthe organic phase washed
5. customdried
6. concentrationconcentrated on a rotary evaporator
7. customThe residue is chromatographed on silica gel (eluant: n-hexane)