反应详情

40 ml of a solution of 45 (mmoles) of 2-chlorocarbonyl-1H-pyrrole in methylene chloride were added dropwise to a cold mixture of 4.3 ml of pyridine and 3.5 ml of methanol and the mixture was washed with water, then with 6 ml of N sodium hydroxide, and was extracted with methylene chloride. The organic phases were dried and concentrated to dryness and the residue was chromatographed over silica. Elution with a mixture of hexane and ethyl acetate (8-2) yielded 4.014 g of methyl 1H-pyrrole-2-carboxylate melting at ≃74° C.

1. washthe mixture was washed with water
2. extractionwith 6 ml of N sodium hydroxide, and was extracted with methylene chloride
3. customThe organic phases were dried
4. concentrationconcentrated to dryness
5. customthe residue was chromatographed over silica
6. washElution
7. additionwith a mixture of hexane and ethyl acetate (8-2)