2-O-Benzyl-3-O-(2'-bromoethyl)carbamoyl-1-O-octadecylglycerol → 3-O-(2'-Bromoethyl)carbamoyl-1-O-octadecylglycerol

Participants

Reaction Steps

A 40 ml portion of 90% aqueous acetic acid solution was added to 949 mg (1.623 mmole) of 2-benzyl-3-O-(2'-bromoethyl)carbamoyl-1-octadecylglycerol (as synthesized in Example 7) and 250 mg of 10% Pd/C, and hydrogenolysis was carried out at room temperature for 2 hours. After the catalyst was filtered out, the filtrate was concentrated under reduced pressure, and a mixture of n-hexane-ethyl acetate (2:1) was added to the residue. The precipitate was collected by filtration to give 785 mg (97.8 g) of the alcohol derivative (colorless powder).

Provenance & Evidence