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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 64907Generated: October 25, 2026

Ammonium Hydroxide → (3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

https://huagongshe.com/reaction/64907

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmonium HydroxideHCID 14923—
Reactant2,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 10867360—
Product(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrileHCID 10943936—

Reaction Steps

The title compound was prepared by stirring 6-cyano-3,4-dihydro-2,2-dimethyl-3,4-epoxy-2H-benzo[b]pyran in ethanolic ammonium hydroxide solution at room temperature until thin layer chromatography showed consumption of the starting epoxide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04610992
Source datasetuspto-grants-1986_09
ORD IDord-d2f313d8d1324931b05ea8e41b0c2890
Source noteuspto-grants-1986_09