Hydrazine → BOC-Lys(CBZ)-Gln-Nle-NHNH2

Participants

Reaction Steps

The tripeptide methyl ester (XIII) (1 g, 1.6 mmol) was suspended in DMF (5 ml), hydrazine (0.8 g, 0.78 ml, 16 mmol) was added and the mixture was stirred overnight. The solvent was removed in vacuo and the residue solidified using MeOH/EtOAc to give (XIV) (0.9 g, 90%). T.l.c. RfA3 =0.70 This was used immediately in the next step.

Provenance & Evidence