HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-methane-sulphonyl-3-(2-chloro-5-trifluoromethylphenoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methanesulfonamide | HCID 72879 | — |
| Reactant | Methyl 5-(2-amino-6-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoate | HCID 21287078 | — |
| Reactant | 5-[2-chloro-5-(trifluoromethyl)phenoxy]-N-methanesulfonyl-2-nitrobenzamide | HCID 21287079 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-methane-sulphonyl-3-(2-chloro-5-trifluoromethylphenoxy)benzamide | HCID 21287082 | — |
Reaction Steps
The acid from (b) (0.8 g) was treated with thionyl chloride followed by methanesulphonamide and pyridine as described in paragraph (d) above for compound 32. The product was recrystallised from a mixture of ether and petroleum (b.p. 40°-60°) to give compound 31 with a melting point of 132°-133°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04738711 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-2b42f58b0a8f4fe9a76680de0ac5b5c8 |
| Source note | uspto-grants-1988_04 |