4-Methoxyphenol → HCID 20142094, compound

HRID 649108Notes

Reaction equation

HRID 649108 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([Cl:12])=[CH:7][CH:6]=2.C[O:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1.Br[CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25].FC1C=[N+]([O-])C2C(C=1[N+]([O-])=O)=CC=CC=2>>[Cl:12][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N:4]=[CH:3][C:2]([O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH:23]([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:17][CH:16]=1)=[CH:11]2

Participants

5

Reactant 4

HCID 90154-MethoxyphenolHCID 79040Ethyl 2-bromopropionateHCID 87158Quinoline, 3-fluoro-4-nitro-, 1-oxideHCID 153784653-Bromo-6-chloroquinoline

Product 1

HCID 20142094HCID 20142094, compound

Procedure

Ethyl 2-{4-[(6-chloroquinolin-3-yl)oxy]phenoxy}propionate (7) was prepared from 3-bromo-6-chloroquinoline, 4-methoxyphenol and ethyl 2-bromopropionate following essentially the same procedure as that described in Example 1 parts (a), (b) and (c). The product recrystallised from methanol as colourless crystals, mp 98° C.

Workup

  1. customThe product recrystallised from methanol as colourless crystals, mp 98° C.

Sources & evidence

ORD record
ord-25e6a118854445dd9dd930d0e2de067b
Source dataset
uspto-grants-1988_04
Patent number
US04738710

Reaction notes

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