Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 20142084, compound

HRID 649110Notes

Reaction equation

HRID 649110 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)=[CH:5]2.Br[C:21]([CH3:28])([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:21]([CH3:28])([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:15][CH:14]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20142080HCID 20142080, compound

Product 1

HCID 20142084HCID 20142084, compound

Procedure

Ethyl 2-{4-[(6-chloroquinolin-3-yl)oxy]phenoxy}-2-methylpropionate (13) was prepared from 4-[(6-chloroquinolin-3-yl)oxy]phenol and ethyl 2-bromo-2-methylpropionate following essentially the same procedure as that described in Example 1 part (c). The product, a pale yellow oil, was characterised by mass spectrometry. Mass spectrum (m/e, %): 387 (M+, 13); 385 (M+, 35), 271 (100).

Sources & evidence

ORD record
ord-ddc49d4d4b24496c82eaa49129d6ff7c
Source dataset
uspto-grants-1988_04
Patent number
US04738710

Reaction notes

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