Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 20142092, compound

HRID 649112Notes

Reaction equation

HRID 649112 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([O:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH:8]=[N:9]2)=[CH:4][CH:3]=1.Br[C:21]([CH3:28])([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([O:12][C:13]3[CH:14]=[CH:15][C:16]([O:19][C:21]([CH3:28])([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:17][CH:18]=3)[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20142083HCID 20142083, compound

Product 1

HCID 20142092HCID 20142092, compound

Procedure

Ethyl 2-{4-[(7-chloroquinolin-3-yl)oxy]phenoxy}-2-methylpropionate (15) was prepared from 4-[(7-chloroquinolin-3-yl)oxy]phenol and ethyl 2-bromo-2-methylpropionate following essentially the same procedure as that described in Example 1 part (c). The product, a pale yellow oil was characterised by proton magnetic resonance spectroscopy. Pmr spectrum (CDCl3 ; δ in ppm): 8.65 (1H, d); 7.95 (1H, bs); 7.35 (3H, m); 6.9 (4H, s); 4.2 (2H, q); 1.6 (6H, s); 1.2 (3H, t).

Sources & evidence

ORD record
ord-5f04f2d949104b5397d4b1885a014014
Source dataset
uspto-grants-1988_04
Patent number
US04738710

Reaction notes

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