Ammonia → HCID 20142073, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated ammonia was added at 20° C. to a solution of ethyl 2-[4-(7-chloroquinolin-3-yloxy)phenoxy]propionate (3.0 g) (see Example 5) in acetone (50 ml) until the mixture just began to turn cloudy. The mixture was then heated at 60° C. for 8 hours and allowed to cool and stand overnight. Colourless crystals (1.5 g) 2-[4-(7-chloroquinolin-3-yloxy)phenoxy]propionamide were collected by filtration. The compound was characterised by its proton magnetic resonance spectrum. (Table 3).

Provenance & Evidence