N,N-Dimethylethylenediamine → HCID 178483769, compound

Participants

Reaction Conditions

Reaction Steps

6-Formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid (520 mg, 1.73 mmoles) was suspended in 15 ml of dry dimethylformamide (DMF) and 1,1'-carbonyldiimidazole (700 mg, 4.32 mmoles) dissolved in 4 ml of DMF was added. The reaction mixture was stirred for 20 minutes at 25° C. until a clear solution had formed. The solution was then cooled in an ice bath and N,N-dimethylethylenediamine (0.6 ml) added. After stirring for 15 minutes at 25° C. the excess reagents were removed under vacuum to yield N-[2-(dimethylamino)ethyl]-6-[[[2-(dimethylamino)ethyl]imino]methyl]-4, 7,9-trihydroxy-1-phenazinecarboxamide. The retention time for this product in the HPLC system described above in Example 3 is 5.0 minutes.

Provenance & Evidence