反应详情

To 20 ml of methanol were added 1 g of 6-(3-bromophenyl)-3(2H)-pyridazinone, 0.13 g of paraformaldehyde and 0.35 g of morpholine, and the resulting mixture was heated under reflux for 2 hours. The reaction mixture was then left to cool, after which the methanol was distilled off under reduced pressure. The residue was recrystallised from a 1:1 by volume mixture of ethyl acetate and hexane, to afford 0.76 g (yield 54%) of the desired Compound No. 26, melting at 110°-111° C.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. waitThe reaction mixture was then left
4. temperatureto cool
5. distillationafter which the methanol was distilled off under reduced pressure
6. customThe residue was recrystallised from a 1:1 by volume mixture of ethyl acetate and hexane