HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-5-bromo-1,3,4-thiadiazole | HCID 3650883 | — |
| Reactant | HCID 19804246 | HCID 19804246 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine | HCID 13541111 | — |
Reaction Steps
0.57 g (2.3 mmol) of 1-Amino-[3-[3-(1-piperidinomethyl)phenoxy]-propane, 0.35 ml of triethylamine and 0.42 g (2,3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amine are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the residue is purified by preparative layer chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04738960 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-23ac849ad05746278524037b3d8a1357 |
| Source note | uspto-grants-1988_04 |