HCID 23035477, compound → HCID 178516503, compound

Participants

Reaction Steps

2-[3-[3-(Piperidinomethyl)phenoxy]propylamino]-4-ethoxyquinoline (liberated from the dimaleate (3.0 g)) was stirred under reflux in concentrated hydrochloric acid (30 ml) for 41/2 hours. The reaction mixture was cooled, reduced in volume by evaporation under reduced pressure, taken to pH 9 (aqueous NaHCO3), washed with ether, and extracted into chloroform (3 x). The chloroform extracts were combined, dried (MgSO4), evaporated under reduced pressure and the resultant white oil was treated with hot ethylacetate to give the title compound (0.89 g), m.p. 171°-171.5° C. (recrystallised from methanol).

Provenance & Evidence